Interruption of Sneddon-Wilkinson Subcorneal Pustulation with Infliximab
نویسندگان
چکیده
منابع مشابه
Interruption of Sneddon-Wilkinson Subcorneal Pustulation with Infliximab
Subcorneal pustular dermatosis (SCPD, Sneddon-Wilkinson disease) is a rare chronic-relapsing skin disorder that typically manifests as flaccid sterile pustules without systemic symptoms. Although the accumulation of neutrophils is acknowledged to be a hallmark of SCPD, its exact pathomechanism is still not known. Several chemotactic factors have been implicated in neutrophil recruitment and inv...
متن کامل[subcorneal Pustular Dermatosis. (sneddon-wilkinson Disease)].
Subcorneal pustular dermatosis is a disease that has coalescent, flaccid, recurrent pustules. We do not know everything about its etiology or pathogenesis; however, its autoimmune mechanism links it with neoplastic or immunologic diseases. First line treatment is dapsone. We describe the case of a classic subcorneal pustular dermatosis in a patient in who we could not use dapsone (sulpha drugs ...
متن کاملInfliximab (anti-tumor necrosis factor alpha antibody): a novel, highly effective treatment of recalcitrant subcorneal pustular dermatosis (Sneddon-Wilkinson disease).
A 79-year old woman presented with a 7-year history of subcorneal pustular dermatosis (SPD). Primary lesions presented as widespread symmetrical eruptions with erythema and flaccid pustules of up to 5 mm in diameter (Figure 1A). Diagnosis was based on the clinical symptoms and the characteristic histologic finding of subcorneal sterile pustules in several skin biopsy specimens (Figure 2A). The ...
متن کاملA child with subcorneal pustular dermatosis responded to IVIG treatment (Sneddon-Wilkinson disease)
Subcorneal pustular dermatosis (SPD) is a rare, chronic, recurrent dermatosis characterised by sterile pustules. It develops mainly in middle-aged or elder women, but is also rarely seen in children. The exact aetiology of the disease is unknown. In literature, cases associated with IgA gammopathy have been reported. In this article; we report a case of a five-year-old girl who was diagnosed as...
متن کاملSneddon-Wilkinson disease treated with etanercept: report of two cases.
Sneddon-Wilkinson disease (SWD), also known as subcorneal pustular dermatosis, is a rare, chronic eruption that is often difficult to treat, particularly in patients who do not respond to or cannot tolerate dapsone. Few case reports exist of patients with SWD treated with antitumour necrosis factor-alpha therapy. We report two patients with SWD refractory to numerous treatments, who responded t...
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ژورنال
عنوان ژورنال: Case Reports in Dermatology
سال: 2017
ISSN: 1662-6567
DOI: 10.1159/000468917